Restoring leukemia cell function from the inside out

Restoring leukemia cell function from the inside out.

In this issue of Blood, Garzon et al and Kuruvilla et al report on the results of phase 1 dose-escalation studies of selinexor in patients with acute myeloid leukemia (AML) and different subtypes of non-Hodgkin lymphoma (NHL), respectively. Together the studies report on 174 patients (95 with AML and 79 with NHL) treated. The drug appears to be tolerable in most patients, with mostly grade 1 or...

From the inside, looking out

Kitchens play a role in the daily life of the family. Kitchens in rural areas of developing countries have some specific characteristics in common; lack of comfort, difficult access to water, poor structures, lack of efficient ventilation, and a lot of smoke. The studies about kitchens have been analyzing diverse aspects, like the stove, the functions, and the climate. Little, if nothing was st...

Studying the Mind from the Inside Out

Good research requires, among other virtues, (i) methods that yield stable experimental observations without arbitrary (post hoc) assumptions, (ii) logical interpretations of the sources of observations, and (iii) sound inferences to general causal mechanisms explaining experimental results by placing them in larger explanatory contexts. In The New Phrenology, William Uttal examines the researc...

α-Tubulin acetylation from the inside out.

P osttranslational modification of proteins, including phosphorylation, ubiquitylation, and acetylation, is an important means of signaling and functional specialization in the cell. The acetylation of lysine residues is best understood in histone proteins, in which histone acetyltransferases modify histone tail sequences to regulate chromatin structure. However, lysine acetylation has recently...

Threatening ocean life from the inside out.